Immunohistochemical expression of receptor tyrosine kinase PDGFR-α, c-Met, and EGFR in skull base chordoma

@article{AkhavanSigari2014ImmunohistochemicalEO,
  title={Immunohistochemical expression of receptor tyrosine kinase PDGFR-α, c-Met, and EGFR in skull base chordoma},
  author={Reza Akhavan-Sigari and Mehdi Abili and Michael Robert Gaab and Veit Rohde and Nadeem Zafar and Pedram Emami and Helmut Ostertag},
  journal={Neurosurgical Review},
  year={2014},
  volume={38},
  pages={89-99}
}
Chordomas are rare, locally aggressive malignancies that often exhibit an insidious natural history and are difficult to eradicate. Surgery and radiotherapy are the treatment mainstays of chordoma, but the chance of local recurrence remains high. Reports of receptor tyrosine kinase (RTK) expression in chordoma suggest that these tumors may respond to kinase inhibitor therapy. Currently, there are no effective chemotherapeutic protocols for chordoma. A tissue microarray containing 74 tumor… CONTINUE READING
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