Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa.

@article{Visca1999ImmunohistochemicalEO,
  title={Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa.},
  author={Paolo Visca and Piero Luigi Al{\`o} and Franca del Nonno and Claudio Botti and Giorgio Trombetta and Ferdinando Marandino and Stefania Filippi and Ugo Di Tondo and Raffaele Perrone Donnorso},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1999},
  volume={5 12},
  pages={4111-8}
}
The normal mucosa-adenoma-carcinoma sequence in colon pathology provides an attractive model of tumor progression. The role of tumor suppressor genes, oncogenes, and proliferative markers in tumorogenesis has evolved considerably in the last decade. By immunohistochemistry means, we have studied p53, bcl-2, c-myc, p21-ras, ki67, and fatty acid synthase (a fatty-acid-synthesizing enzyme) in normal, dysplastic, and neoplastic mucosa. The results were correlated with clinicopathological features… CONTINUE READING
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Apoptosis 4117 Clinical Cancer

  • G. B. Baretton, J. Diebold, +6 authors U. Lohrs
  • Research Research. on October
  • 1999
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