Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors.

@article{Demirkan2007ImmunohistochemicalEO,
  title={Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors.},
  author={Neşe Calli Demirkan and Ferda Bir and Ozlem Erdem and Ender D{\"u}zcan},
  journal={Journal of cutaneous pathology},
  year={2007},
  volume={34 6},
  pages={467-73}
}
BACKGROUND beta-catenin gene mutations have been reported in vast majority of pilomatrixomas (PMXs). beta-catenin, a component of the adhesion molecules of the cytoskeleton, is degraded at the cytoplasm. Excess cytoplasmic beta-catenin enters into the nucleus and activates the transcription of several genes encoding c-myc, cyclin D1 and others. Sublocation… CONTINUE READING