Immunohistochemical expression of WT1 by desmoplastic small round cell tumor: a comparative study with other small round cell tumors.

@article{Barnoud2000ImmunohistochemicalEO,
  title={Immunohistochemical expression of WT1 by desmoplastic small round cell tumor: a comparative study with other small round cell tumors.},
  author={Rapha{\"e}lle Barnoud and Jean Christophe Sabourin and Dominique Pasquier and Dominique Ranch{\`e}re and Christiane Bailly and M. J. Terrier-Lacombe and Basile M. Pasquier},
  journal={The American journal of surgical pathology},
  year={2000},
  volume={24 6},
  pages={830-6}
}
Desmoplastic small round cell tumors (DSRCTs) present a reciprocal chromosomal translocation, t(11;22)(p13;q12), that results in fusion of Ewing's sarcoma and Wilms' tumor (WT1) genes. The authors evaluated 15 DSRCTs and 71 other tumors often considered in the differential diagnosis for immunoreactivity using a polyclonal antibody directed against the WT1 part of the chimeric protein resulting from this translocation. WT1 immunostaining was performed on paraffin material using the WT(C-19… CONTINUE READING
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