Immunohistochemical expression of SNAP-25 protein in adenomas of the human pituitary.

  title={Immunohistochemical expression of SNAP-25 protein in adenomas of the human pituitary.},
  author={Fabio Rotondo and K{\'a}lm{\'a}n Kov{\'a}cs and Bernd Walter Scheithauer and Eva Horv{\'a}th and Cecil David Bell and Ricardo Vincent Lloyd and Michael D. Cusimano},
  journal={Applied immunohistochemistry & molecular morphology : AIMM},
  volume={16 5},
SNAP-25, a synaptosome-associated exocytosis protein of 25 kd mw, plays an important role in the secretory activity of several endocrine cells. In the present study, we investigated surgically removed pituitary adenomas including 40 prolactin (PRL), 31 growth hormone, 5 adrenocorticotropic hormone, 5 thyroid-stimulating hormone, 14 follicle-stimulating hormone/luteinizing hormone/alpha-subunit-producing tumors, and 5 null cell adenomas. Among the 40 patients with PRL-producing pituitary adenoma… CONTINUE READING
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