Immunohistochemical expression of FHIT gene product in inflammatory bowel disease: significance and correlation with clinicopathological data.

@article{Skopelitou2003ImmunohistochemicalEO,
  title={Immunohistochemical expression of FHIT gene product in inflammatory bowel disease: significance and correlation with clinicopathological data.},
  author={Antigone S. Skopelitou and Konstantinos H. Katsanos and Michael Michail and Antigone Mitselou and Epameinondas Tsianos},
  journal={European journal of gastroenterology & hepatology},
  year={2003},
  volume={15 6},
  pages={665-73}
}
OBJECTIVE To investigate the expression of Fhit protein in 53 patients with ulcerative colitis and Crohn's disease, as well as in 13 ulcerative-colitis-associated adenocarcinomas, and its eventual relationship with clinicopathological data and response to therapy. MATERIALS AND METHODS We performed immunohistochemistry in archival material of formalin-fixed, paraffin-embedded tissues using the anti-Fhit antibody and the streptavidin-biotin peroxidase method. RESULTS In 35/38 cases of… CONTINUE READING

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