Immunohistochemical expression of Bcl-2, Bax and cytochrome c following focal cerebral ischemia and effect of hypothermia in rat.

@article{Babu2000ImmunohistochemicalEO,
  title={Immunohistochemical expression of Bcl-2, Bax and cytochrome c following focal cerebral ischemia and effect of hypothermia in rat.},
  author={P Prakasa Babu and Yoshihiro Yoshida and M H Su and M. Garcia Segura and Seiji Kawamura and Naoko Yasui},
  journal={Neuroscience letters},
  year={2000},
  volume={291 3},
  pages={196-200}
}
Recent studies suggest that mild hypothermia significantly alleviate damage following cerebral ischemia though the precise mechanism is poorly defined. In the present study, middle cerebral artery occlusion (MCAo) was induced in Sprague-Dawley (SD) rats for 1 h followed by varying periods of reperfusion. Cerebral infarcts identified by hematoxylin & eosin (H&E) staining revealed extensive lesion in normothermic (NT) 37 degrees C and small lesion in hypothermic (HT) 33 degrees C group of rats… CONTINUE READING
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