Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.

@article{Billov2007ImmunohistochemicalEA,
  title={Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.},
  author={Sabina Billov{\'a} and Aristea S Galanopoulou and Nabil G Seidah and X Qiu and Ujendra Kumar},
  journal={Neuroscience},
  year={2007},
  volume={147 2},
  pages={403-18}
}
The processing of many peptides for their maturation in target tissue depends upon the presence of sorting receptor. Several previous studies have predicted that carboxypeptidase-E (CPE), prohormone convertase 1 (PC1) and prohormone convertase 2 (PC2) may function as sorting elements for somatostatin (SST) for its maturation and processing to appropriate targets. However, nothing is currently known about whether brain, neuronal culture or even endocrine cells express SST, CPE, PC1 and PC2 and… CONTINUE READING