Immunohistochemical evidence of dysregulation of the mammalian target of rapamycin pathway in primary and metastatic pheochromocytomas.

@article{Chaux2012ImmunohistochemicalEO,
  title={Immunohistochemical evidence of dysregulation of the mammalian target of rapamycin pathway in primary and metastatic pheochromocytomas.},
  author={Alcides M Chaux and Fadi Brimo and Nilda D Gonzalez-Roibon and Smit Shah and Luciana Schultz and Jean-Marc Rizk and Pedram Argani and Jessica L. Hicks and George J Netto},
  journal={Urology},
  year={2012},
  volume={80 3},
  pages={736.e7-12}
}
OBJECTIVE To characterize the status of the mammalian target of rapamycin pathway using formalin-fixed, paraffin-embedded specimens from patients with primary and metastatic pheochromocytoma. METHODS Tissue microarrays were built from 19 normal adrenal medullas, 39 primary pheochromocytomas, and 8 unrelated metastatic pheochromocytomas. In 2 of the 8 cases of metastatic pheochromocytoma tissues, samples from the primary tumor were available. The expression levels of phosphatase and tensin… CONTINUE READING