Immunohistochemical evidence for the expression and induction of paraoxonase in rat liver, kidney, lung and brain tissue. Implications for its physiological role.

@article{Rodrigo2001ImmunohistochemicalEF,
  title={Immunohistochemical evidence for the expression and induction of paraoxonase in rat liver, kidney, lung and brain tissue. Implications for its physiological role.},
  author={Lourdes Rodrigo and Antonio F. Hern{\'a}ndez and J J L{\'o}pez-Caballero and Francisco Gil and A. Plana Pla},
  journal={Chemico-biological interactions},
  year={2001},
  volume={137 2},
  pages={123-37}
}
Studies on the localization of paraoxonases (PON's) are of interest because of its involvement in both the detoxication of activated organophosphorus pesticides and in the prevention of peroxidative damage to phospholipids and cholesteryl-esters in LDL and HDL particles and cell membranes during the atherogenic process. In the present study, we have investigated the cellular localization of PON1 by immunohistochemistry in different rat tissues. The protein was mainly detected in the endothelial… CONTINUE READING