Immunohistochemical distribution of c-erbB-2 in infiltrating and in situ breast cancer.

  title={Immunohistochemical distribution of c-erbB-2 in infiltrating and in situ breast cancer.},
  author={Barry Gusterson and L. G. Machin and William J. Gullick and Neville M Gibbs and Trevor J. Powles and Patricia Price and Alan McKinna and Steadman D. Harrison},
  journal={International journal of cancer},
  volume={42 6},
An immunohistochemical study of c-erbB-2 expression was performed on invasive and in situ breast cancer. Strong membrane staining was seen in 16% of the infiltrating ductal carcinomas and 44% of the in situ lesions. c-erbB-2 was overexpressed in ductal rather than lobular tumours. Our results indicate that a small sub-group of breast carcinomas are associated with over-expression of this oncogene which may define an important subgroup of in situ and infiltrating ductal carcinomas. 

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