Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma.

@article{Watanabe2009ImmunohistochemicalDO,
  title={Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma.},
  author={Fumiaki Watanabe and Motoshi Takao and Kentarou Inoue and Junji Nishioka and Tsutomu Nobori and Taizo Shiraishi and Masanori Kaneda and Takashi Sakai and Isao Yada and Hideto Shimpo},
  journal={Lung cancer},
  year={2009},
  volume={63 1},
  pages={39-44}
}
Methylthioadenosine phosphorylase (MTAP) is involved in the metabolism of purines and converts methylthioadenosine (MTA) to adenine. It is abundant in all normal tissues but is deficient in various tumors. Here, we investigated MTAP deficiency in clinical samples of lung cancer using immunohistochemistry (IHC), and compared these results with those obtained by real-time PCR. Seventy-five samples were obtained from patients who underwent operations for non-small cell lung cancer (NSCLC). MTAP… CONTINUE READING
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