Immunohistochemical detection of phosphorylated Akt, PI3K, and PTEN in ameloblastic tumors.

@article{Kumamoto2007ImmunohistochemicalDO,
  title={Immunohistochemical detection of phosphorylated Akt, PI3K, and PTEN in ameloblastic tumors.},
  author={Hiroyuki Kumamoto and Kiyoshi Ooya},
  journal={Oral diseases},
  year={2007},
  volume={13 5},
  pages={461-7}
}
OBJECTIVE To evaluate roles of the Akt signaling pathway in oncogenesis and cytodifferentiation of odontogenic tumors, expression of phosphorylated Akt (pAkt), PI3K, and PTEN was analyzed in ameloblastic tumors as well as in tooth germs. METHODS 11 tooth germs, 40 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with antibodies against pAkt, PI3K, and PTEN. RESULTS Immunoreactivity for pAkt, PI3K, and PTEN was detected predominantly in odontogenic… CONTINUE READING
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