Immunohistochemical detection of p53 protein overexpression versus gene sequencing in urinary bladder carcinomas.

@article{Bernardini1999ImmunohistochemicalDO,
  title={Immunohistochemical detection of p53 protein overexpression versus gene sequencing in urinary bladder carcinomas.},
  author={Sergio Bernardini and G{\'e}rard L. Adessi and Claude Billerey and E Chezy and Jean Pierre Carbillet and Hugues Bittard},
  journal={The Journal of urology},
  year={1999},
  volume={162 4},
  pages={1496-501}
}
PURPOSE Mutations of p53 tumor suppressor gene and nuclear accumulation of p53 protein are common in bladder tumors. The prognostic significance of p53 alterations in bladder tumors has not been established. The aim of the present study was to evaluate an immunohistochemical (IHC) method for the routine determination of p53 protein overexpression in human bladder tumors and to determine the relation between nuclear accumulation of p53 with the traditional prognostic indicators and patient… CONTINUE READING
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