Immunohistochemical detection of p53 protein in basal cell skin cancer after microwave-assisted antigen retrieval


p53 is the most frequently altered tumor-suppressor gene in skin cancer. In normal tissues the p53 protein (wild type) has a very short half-life and it is not detectable immunohistochemically. In contrast, the mutant p53 protein has an extended half-life in tumor cells and can be detected by immunohistochemical methods. p53 is widely used as an indicator… (More)
DOI: 10.1007/s10735-008-9208-8


10 Figures and Tables