Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise.

@article{Penkowa2003ImmunohistochemicalDO,
  title={Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise.},
  author={Milena Penkowa and Charlotte Keller and Pernille Keller and Sune Jauffred and Bente Klarlund Pedersen},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 14},
  pages={
          2166-8
        }
}
Interleukin-6 (IL-6) is produced by many different cell types. Human skeletal muscles produce and release high amounts of IL-6 during exercise; however, the cell source of origin in the muscle is not known. Therefore, we studied the protein expression of IL-6 by immunohistochemistry in human muscle tissue from biopsies obtained at time points 0, 3, 4.5, 6, 9, and 24 h in relation to 3 h of bicycle exercise performed by healthy young males (n=12) and in resting controls (n=6). The IL-6… CONTINUE READING

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Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity.

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