Immunohistochemical detection of an estrogen-regulated protein by monoclonal antibodies.

  title={Immunohistochemical detection of an estrogen-regulated protein by monoclonal antibodies.},
  author={Daniel Ram{\'o}n Ciocca and David J Adams and Robert J. Bjercke and Dean P. Edwards and William L. McGuire},
  journal={Cancer research},
  volume={42 10},
It has been shown previously that estradiol regulates the synthesis of a Mr 24,000 cytosol protein in MCF-7 human breast cancer cells. This protein is an attractive probe to study the mechanisms of estrogen regulation in human breast cancer. We have produced monoclonal antibodies against the Mr 24,000 protein which show immunocytochemical localization in the cytoplasm of MCF-7 cells grown as solid tumors in nude mice. They do not react with normal mouse tissue or with MDA-MB-231 cells, an… CONTINUE READING


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