Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors.

  title={Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors.},
  author={Hiroyuki Kumamoto and Kiyoshi Ooya},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  volume={35 6},
BACKGROUND To evaluate the roles of matrix-degrading proteinase regulators in progression of odontogenic tumors, expression of membrane-bound matrix metalloproteinase (MMP) MT1-MMP, MMP inhibitor RECK and MMP inducer EMMPRIN was analyzed in ameloblastic tumors as well as in tooth germs. METHODS Tissue specimens of 11 tooth germs, 40 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against MT1-MMP, RECK, and EMMPRIN… CONTINUE READING
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