Immunohistochemical detection of Human Papillomavirus capsid proteins L1 and L2 in squamous intraepithelial lesions: Potential utility in diagnosis and management

@inproceedings{Yemelyanova2013ImmunohistochemicalDO,
  title={Immunohistochemical detection of Human Papillomavirus capsid proteins L1 and L2 in squamous intraepithelial lesions: Potential utility in diagnosis and management},
  author={Anna V. Yemelyanova and P Gravitt and BM Ronnett and A F Rositch and Aleksandra Ogurtsova and JD Seidman and R Roden},
  booktitle={Modern Pathology},
  year={2013}
}
While cervical cancer screening relies on cervical cytology and high-risk human papillomavirus (HPV) detection, the histologic diagnosis, and specifically lesion grade, is the main parameter that drives clinical management of screen-positive women. Morphologically diagnosed squamous intraepithelial lesions (SIL/CIN) regress spontaneously in more than half of the cases, but identifying those likely to persist and progress is not currently possible based upon morphology. Lack of major capsid… CONTINUE READING