Immunohistochemical detection of GHRH and its receptor splice variant 1 in primary human breast cancers.

@article{Chatzistamou2004ImmunohistochemicalDO,
  title={Immunohistochemical detection of GHRH and its receptor splice variant 1 in primary human breast cancers.},
  author={Ioulia Chatzistamou and Andrew V Schally and Hippokratis Kiaris and Ekaterini Politi and J{\'o}zsef L. Varga and George Kanellis and Anastasios Th Kalofoutis and Agatha Pafiti and Helen A Koutselini},
  journal={European journal of endocrinology},
  year={2004},
  volume={151 3},
  pages={391-6}
}
OBJECTIVE GHRH is secreted by the hypothalamus and, upon binding to specific GHRH receptors in the pituitary, stimulates growth hormone (GH) production and release from the pituitary. In addition to this neuroendocrine action, accumulated evidence implies additional roles for GHRH in carcinogenesis in non-pituitary tissues. In vitro and in vivo studies have shown that splice variant 1 (SV1) of the GHRH receptor, which is widely expressed in non-pituitary tissues and cancers, can mediate the… CONTINUE READING