Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance.

@article{Aldape2004ImmunohistochemicalDO,
  title={Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance.},
  author={Kenneth D. Aldape and Karla A Ballman and Alfred Furth and Jan C. Buckner and Caterina Giannini and Peter C. Burger and Bernd Walter Scheithauer and R. Brian Jenkins and C. David James},
  journal={Journal of neuropathology and experimental neurology},
  year={2004},
  volume={63 7},
  pages={700-7}
}
The purpose of this study was to establish an accurate and accessible immunohistochemical (IHC) method for detecting vIII Egf receptor and to assess the prognostic significance of the method as applied to the detection of vIII in malignant astrocytomas. The accuracy of the method was determined by comparing vIII immunoreactivity in formalin-fixed and paraffin-embedded tumor sections versus RT-PCR results from the analysis of RNA extracted from corresponding frozen specimens. RT-PCR revealed… CONTINUE READING

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