Immunohistochemical demonstration of the gamma2 chain of laminin-5 in urinary bladder urothelial carcinoma. Impact for diagnosis and prognosis.

@article{Hindermann2003ImmunohistochemicalDO,
  title={Immunohistochemical demonstration of the gamma2 chain of laminin-5 in urinary bladder urothelial carcinoma. Impact for diagnosis and prognosis.},
  author={Winfried Hindermann and Alexander Berndt and Karl Michael Haas and Heiko Wunderlich and Detlef Katenkamp and Hartwig Kosmehl},
  journal={Cancer detection and prevention},
  year={2003},
  volume={27 2},
  pages={109-15}
}
The heterotrimeric molecule laminin-5 (Ln-5) represents a main protein of the epithelial adhesions complex. It links the basement membrane (BM) with the hemidesmosomes of the basal urothelial cells. The study was aimed to evaluate invasion associated changes of the epithelial adhesion complex in urothelial carcinoma (UC) monitored by immunohistochemical demonstration of the Ln-5 gamma2 chain. For correlation to UC phenotype and patients outcome, a semiquantitative immunohistochemical analysis… CONTINUE READING
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