Immunohistochemical demonstration of nociceptors in the capsule and synovial folds of human zygapophyseal joints.

@article{Giles1987ImmunohistochemicalDO,
  title={Immunohistochemical demonstration of nociceptors in the capsule and synovial folds of human zygapophyseal joints.},
  author={Lynton G. F. Giles and Alan R Harvey},
  journal={British journal of rheumatology},
  year={1987},
  volume={26 5},
  pages={362-4}
}
Substance P, a physiologically potent neuropeptide, is considered to participate in nociceptive transmission of nerve impulses. Substance P immunofluorescent nerves are demonstrated in the inferior joint recess capsule and its synovial folds in human lumbosacral zygapophyseal joints. This may have clinical significance in spinal pain.