Immunohistochemical demonstration of neuron-specific enolase and microtubule-associated protein 2 in reactive astrocytes after injury in the adult forebrain.

@article{Lin1994ImmunohistochemicalDO,
  title={Immunohistochemical demonstration of neuron-specific enolase and microtubule-associated protein 2 in reactive astrocytes after injury in the adult forebrain.},
  author={R. S. Lin and Diane F. Matesic},
  journal={Neuroscience},
  year={1994},
  volume={60 1},
  pages={11-6}
}
Transformation of normal resting astrocytes to reactive astrocytes in the adult brain after injury has been well documented. Using double immunofluorescent labeling methods, we report that astrocytes in both the ischemically damaged and the retrogradely/anterogradely degenerating forebrain nuclei express not only the glial cell markers glial fibrillary acidic protein and vimentin, but also the neuronal markers neuron-specific enolase and microtubule-associated protein 2. Since these neuronal… CONTINUE READING