Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma

@article{Tatsukawa2016ImmunohistochemicalDO,
  title={Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma},
  author={Ryoko Tatsukawa and Kaori Koga and Mikiko Aoki and Naohiko Koshikawa and Shinichi Imafuku and Juichiro Nakayama and Kazuki Nabeshima},
  journal={Virchows Archiv},
  year={2016},
  volume={469},
  pages={25-34}
}
Erythropoietin-producing hepatocellular receptor-2 (EphA2) overexpression is prevalent in many types of human cancers, and it has been reported that high EphA2 expression is correlated with malignancy. Recent studies revealed that processing of EphA2 by cleaving off the N-terminal portion by membrane-type 1 matrix metalloproteinase (MT1-MMP) promotes invasion via stimulation of Ras in cancer cells in vitro. The objectives of this study were to investigate the presence and role of EphA2… CONTINUE READING