Immunohistochemical comparison of uterine papillary serous and papillary endometrioid carcinoma: clues to pathogenesis.

@article{Demopoulos1999ImmunohistochemicalCO,
  title={Immunohistochemical comparison of uterine papillary serous and papillary endometrioid carcinoma: clues to pathogenesis.},
  author={Rita I. Demopoulos and Augusto F Mesia and Khushbakhat Rai Mittal and Eleftherios C. Vamvakas},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={1999},
  volume={18 3},
  pages={233-7}
}
Twenty-four predominantly papillary carcinomas of the endometrium, 10 serous and 14 endometrioid, were compared using a variety of immunohistochemical antibodies, including p53, estrogen and progesterone receptors, carcinoembryonic antigen, and E-cadherin. These were selected to attempt to find clues to explain the disparate behavior of these two tumor subtypes. We found that 6 of 8 (75%) serous carcinomas had a p53 reactivity score of 300, whereas 90% of endometrioid tumors had a p53… CONTINUE READING

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