Immunohistochemical classification of primary and recurrent macular corneal dystrophy in Germany: subclassification of immunophenotype I A using a novel keratan sulfate antibody.

@article{Cursiefen2001ImmunohistochemicalCO,
  title={Immunohistochemical classification of primary and recurrent macular corneal dystrophy in Germany: subclassification of immunophenotype I A using a novel keratan sulfate antibody.},
  author={Claus Cursiefen and Carmen R Hofmann-Rummelt and Ursula M. Schl{\"o}tzer-Schrehardt and Dagmar Christiane Fischer and H. D. Haubeck and Michael Kuechle and Gottfried Otto Helmut Naumann},
  journal={Experimental eye research},
  year={2001},
  volume={73 5},
  pages={
          593-600
        }
}
Macular corneal dystrophy (MCD) is an autosomal recessive disease characterized by abnormal deposition of glycosaminoglycans in corneal stroma, keratocytes, Descemet's membrane and corneal endothelium. According to the presence and distribution of sulfated keratan sulfate (KS)-epitopes in serum and cornea (using mAb 5-D-4), MCD can be classified into three immunophenotypes: type I, I A and II. The purpose of this study is to evaluate the immunophenotype of primary and recurrent MCD and to… CONTINUE READING
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