Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer.

@article{Shintani2010ImmunohistochemicalCO,
  title={Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer.},
  author={Michiko Shintani and Makoto Urano and Yasunari Takakuwa and Makoto Kuroda and S Kamoshida},
  journal={Oncology reports},
  year={2010},
  volume={23 5},
  pages={1345-50}
}
Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de novo pyrimidine synthesis, respectively. Numerous studies have suggested that increased TS levels are associated closely with resistance to fluoropyrimidine-based chemotherapy. TAS-102 is a novel drug containing trifluorothymidine, which is phosphorylated by TK-1 to its active monophosphated form, that in turn can inhibit TS. TAS-102 has been shown to exhibit antitumor activity in fluoropyrimidine… CONTINUE READING
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