Immunohistochemical characterization of gastrinomas with antibodies specific to different fragments of progastrin.

@article{Sobhani1989ImmunohistochemicalCO,
  title={Immunohistochemical characterization of gastrinomas with antibodies specific to different fragments of progastrin.},
  author={Iradj Sobhani and L Elouaer-Blanc and Th{\'e}r{\`e}se Lehy and Jacques Rahier and Stanislas P. Pauwels and Michel Mignon and Serge Bonfils and Miguel J. M. Lewin},
  journal={Gastroenterologie clinique et biologique},
  year={1989},
  volume={13 11},
  pages={865-72}
}
The characterization of the tumors and their metastasis in patients with the Zollinger-Ellison syndrome is currently based on the immunohistochemical identification of gastrin cells. However, sometimes tumoral cells fail to react with common C-terminal gastrin antibodies. In order to clarify this failure, we carried out morphologic, morphometric and immunocytochemical analyses performed on light and electron microscope levels of 6 pancreatic and 1 metastatic gastrinomas, using antibodies raised… CONTINUE READING
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