Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers.

@article{Palacios2003ImmunohistochemicalCD,
  title={Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers.},
  author={Jos{\'e} Palacios and Emiliano Honrado and A Osorio and Alicia Cazorla and David Sarri{\'o} and Alicia Barroso and Sandra M{\'o}nica Rodriguez and Juan C. Cigudosa and Orland Diez and C. Vaquerizo Alonso and Enrique Lerma and Lydia V. Sanchez and Carmen Sanchez de Rivas and Javier Ben{\'i}tez},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 10 Pt 1},
  pages={3606-14}
}
PURPOSE Most familial breast cancers are not associated with BRCA1 or BRCA2 germ-line mutations. Therefore, it is of major importance to define the morphological, immunohistochemical, and molecular features of this group of tumors to improve genetic testing and also gain further insight into the biological characteristics of tumors. EXPERIMENTAL DESIGN We evaluated the morphological characteristics of 37 tumors arising in women without BRCA1 or BRCA2 mutations, 20 tumors from BRCA1 mutation… CONTINUE READING