Immunohistochemical and in situ localization of Crimean-Congo hemorrhagic fever (CCHF) virus in human tissues and implications for CCHF pathogenesis.

@article{Burt1997ImmunohistochemicalAI,
  title={Immunohistochemical and in situ localization of Crimean-Congo hemorrhagic fever (CCHF) virus in human tissues and implications for CCHF pathogenesis.},
  author={Felicity J Burt and Robert Swanepoel and W. J. Shieh and Jonathan F. Smith and Patricia A. Leman and Patricia W. Greer and L M Coffield and Pierre E. Rollin and Thomas Ksiazek and Clarence J. Peters and Sherif R. Zaki},
  journal={Archives of pathology & laboratory medicine},
  year={1997},
  volume={121 8},
  pages={839-46}
}
BACKGROUND Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal disease that occurs in parts of Africa, Asia, and eastern Europe, and that is caused by a recently emerged bunyavirus. Rapid laboratory diagnosis of CCHF infection is essential and is currently performed by virus isolation and serology. Histopathologic studies have been limited to a small number of cases, and little is known about the cellular tropism of CCHF virus and the pathogenesis of this disease. DESIGN We… CONTINUE READING

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