Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.

@article{McNamara1998ImmunohistochemicalAI,
  title={Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.},
  author={Melissa McNamara and Christian Thomas Ruff and Wilma Wasco and Rudolph E. Tanzi and Gopal Thinakaran and Bradley T. Hyman},
  journal={Brain research},
  year={1998},
  volume={804 1},
  pages={45-51}
}
Amyloid precursor protein (APP) is a ubiquitously expressed membrane spanning glycoprotein which is endoproteolytically processed to Abeta, a 39-43 amino acid peptide that is the main component of senile plaques in Alzheimer Disease (AD). APP is a member of a highly conserved gene family, including Amyloid Precursor-Like Proteins (APLPs) APLP1 and APLP2. We now characterize APLP1 and APLP2 mRNA and protein expression in AD and aged control brains. Using in situ hybridization in hippocampal… CONTINUE READING

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