Immunohistochemical and immunoelectron microscopic demonstration of chromogranin A in formalin-fixed tissue of Merkel cell carcinoma.

@article{Haneke1993ImmunohistochemicalAI,
  title={Immunohistochemical and immunoelectron microscopic demonstration of chromogranin A in formalin-fixed tissue of Merkel cell carcinoma.},
  author={Eckart Haneke and H. J. Schulze and Gustav Mahrle},
  journal={Journal of the American Academy of Dermatology},
  year={1993},
  volume={28 2 Pt 1},
  pages={222-6}
}
BACKGROUND Chromogranin A (CGA) is the major protein of neurosecretory granules (NSG) of cells of the diffuse neuroendocrine system, and the amount of CGA corresponds to the number of NSGs. OBJECTIVE Because formalin fixation may destroy NSGs, a study was performed to examine the presence of CGA in Merkel cell carcinoma (MCC) to determine whether CGA depends on the presence of intact NSGs. METHODS Formalin-fixed, paraffin-embedded tissue of 15 MCCs was investigated by immunohistochemistry… CONTINUE READING

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