Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1.

@article{Tamai1999ImmunohistochemicalAF,
  title={Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1.},
  author={Ikumi Tamai and Yoshimichi Sai and Akira Ono and Yasuto Kido and Hikaru Yabuuchi and Hitomi Takanaga and Eisaku Satoh and Takuo Ogihara and Osamu Amano and S Izeki and Akira Tsuji},
  journal={The Journal of pharmacy and pharmacology},
  year={1999},
  volume={51 10},
  pages={1113-21}
}
The participation of the monocarboxylic acid transporter MCT1 in the intestinal absorption of weak organic acids has been clarified by functional characterization, by use of stably transfected cells, and by immunohistochemical location of the transporter in intestinal tissues. Immunohistochemical analysis by use of the anti-MCT1 antibody showed that MCT1 is distributed throughout the upper and lower intestines, especially in the basolateral membrane and, to a lesser extent, in the brush-border… CONTINUE READING

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