Corpus ID: 46088238

Immunohistochemical analysis using a BRAF V600E mutation specific antibody is highly sensitive and specific for the diagnosis of hairy cell leukemia.

@article{Wang2014ImmunohistochemicalAU,
  title={Immunohistochemical analysis using a BRAF V600E mutation specific antibody is highly sensitive and specific for the diagnosis of hairy cell leukemia.},
  author={Xuan Jun Wang and Annette S. Kim and Shaoying Li},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 7},
  pages={
          4323-8
        }
}
  • Xuan Jun Wang, Annette S. Kim, Shaoying Li
  • Published in
    International journal of…
    2014
  • Biology, Medicine
  • Hairy cell leukemia (HCL) is usually diagnosed by morphology and flow cytometry studies. However, it is challenging sometimes to distinguish HCL from its mimics. Recently, the BRAF V600E mutation has been described as a disease-defining molecular marker for HCL which is present in nearly all cases of HCL but virtually absent in mimics of HCL. In this study, we investigated the possibility of using immunohistochemical detection of the BRAF V600E mutant protein to differentiate HCL from its… CONTINUE READING

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    Hairy Cell Leukemia, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

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    • Applied immunohistochemistry & molecular morphology : AIMM
    • 2015

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