Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads

@article{Verdier2003ImmunohistochemicalAO,
  title={Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads},
  author={Monique Verdier and Sophie Seit{\'e} and K. Guntzer and Juan Ignacio Pujol and Karim Boum{\'e}diene},
  journal={Rheumatology International},
  year={2003},
  volume={25},
  pages={118-124}
}
Osteoarthritis (OA) is characterized by erosion of cartilage and formation of osteophytes. Since transforming growth factor beta (TGF-β) is known to be involved in chondrogenesis and osteogenesis, we studied by immunochemistry the expression of TGF-β isoform types 1, 2, and 3 and their receptor types I and II in slightly and strongly altered areas of human OA cartilage and in osteophytes. Specimens were collected from femoral heads at the time of hip arthroplasty, selecting osteophytic regions… CONTINUE READING
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