Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads

@article{Verdier2003ImmunohistochemicalAO,
  title={Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads},
  author={M. Verdier and S. Seit{\'e} and K. Guntzer and J. Pujol and K. Boum{\'e}diene},
  journal={Rheumatology International},
  year={2003},
  volume={25},
  pages={118-124}
}
  • M. Verdier, S. Seité, +2 authors K. Boumédiene
  • Published 2003
  • Medicine
  • Rheumatology International
  • ObjectiveOsteoarthritis (OA) is characterized by erosion of cartilage and formation of osteophytes. Since transforming growth factor beta (TGF-β) is known to be involved in chondrogenesis and osteogenesis, we studied by immunochemistry the expression of TGF-β isoform types 1, 2, and 3 and their receptor types I and II in slightly and strongly altered areas of human OA cartilage and in osteophytes.MethodsSpecimens were collected from femoral heads at the time of hip arthroplasty, selecting… CONTINUE READING
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