Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis.

@article{Itatsu2007ImmunohistochemicalAO,
  title={Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis.},
  author={Keita Itatsu and Yoh Zen and Shusaku Ohira and Akira Kamagaya-shi Ishikawa and Yasunori Sato and Kenichi Harada and Hiroko Kurimasa Ikeda and Motoko Sasaki and Yoshitugu Nimura and Yasuni Nakanuma},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2007},
  volume={27 9},
  pages={
          1174-84
        }
}
BACKGROUND Two types of precursor lesions, flat-type 'biliary intraepithelial neoplasia (BilIN)' and papillary-type 'intraductal papillary neoplasm of the bile duct (IPNB)', are proposed in the tumorigenesis of intrahepatic cholangiocarcinoma (ICC) in hepatolithiasis. METHODS In this study, the participation of cancer-related molecules in the progression of these two precursor lesions was examined, using 64 hepatolithiatic livers with BilIN lesions (45 livers) and IPNB lesions (19 livers) and… CONTINUE READING
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