Immunohistochemical analysis of cerebral cortical and vascular lesions in the primate Microcebus murinus reveal distinct amyloid beta1-42 and beta1-40 immunoreactivity profiles.

@article{MestreFrancs2000ImmunohistochemicalAO,
  title={Immunohistochemical analysis of cerebral cortical and vascular lesions in the primate Microcebus murinus reveal distinct amyloid beta1-42 and beta1-40 immunoreactivity profiles.},
  author={Nadine Mestre-Franc{\'e}s and Elisabeth Keller and A Calenda and H{\'e}l{\`e}ne Barelli and Fr{\'e}d{\'e}ric Checler and N. Bons},
  journal={Neurobiology of disease},
  year={2000},
  volume={7 1},
  pages={1-8}
}
Recent reports have shown that amyloid beta deposits in the brains of Alzheimer's disease patients consist mainly of two distinct species of amyloid beta protein (Abeta) with different C-termini, Abeta1-42 (Abeta42) and Abeta1-40 (Abeta40). The nature of the Abeta species in Microcebus murinus brain was investigated immunocytochemically using polyclonal antibodies with clear specificity for the Abeta42 and Abeta40 C-termini. The cortical vascular deposits were immunopositive for both Abeta42… CONTINUE READING