Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis

@article{Bernal2002ImmunohistochemicalAO,
  title={Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis},
  author={Fabi{\'a}n Bernal and Francesc Graus and {\`A}lex Pifarr{\'e} and Albert Saiz and Baya Benyahia and Teresa Ribalta},
  journal={Acta Neuropathologica},
  year={2002},
  volume={103},
  pages={509-515}
}
Abstract. The precise immune mechanisms of neuronal death in anti-Hu-associated paraneoplastic encephalomyelitis (PEM) are unclear. We performed an immunohistochemical study on postmortem brain tissue from 11 patients with anti-Hu-associated PEM to further characterize the immune reaction and to ascertain possible mechanisms of neuronal death. To analyze inflammatory infiltrates, antibodies against lymphocyte subpopulations (CD3, CD20, CD4, CD8), macrophage and activated microglia (CD68), major… 
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TLDR
The results do not support a role for HuD-specific CD8+ T cells in Hu-PNS, and further studies should focus on the detection of circulating HuD and Class I HLA multimers in affected tissues.
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The link between PNS emergence and antitumor responses may result from more active CTLs and less functional Treg lymphocytes, which often coincide with a less aggressive course of neoplastic disease.
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TLDR
Findings suggest that an antigen-driven oligoclonal cytotoxic T-cell response plays a role in the pathogenesis of anti-Hu associated PEM/SN.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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