Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis
@article{Bernal2002ImmunohistochemicalAO, title={Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis}, author={Fabi{\'a}n Bernal and Francesc Graus and {\`A}lex Pifarr{\'e} and Albert Saiz and Baya Benyahia and Teresa Ribalta}, journal={Acta Neuropathologica}, year={2002}, volume={103}, pages={509-515} }
Abstract. The precise immune mechanisms of neuronal death in anti-Hu-associated paraneoplastic encephalomyelitis (PEM) are unclear. We performed an immunohistochemical study on postmortem brain tissue from 11 patients with anti-Hu-associated PEM to further characterize the immune reaction and to ascertain possible mechanisms of neuronal death. To analyze inflammatory infiltrates, antibodies against lymphocyte subpopulations (CD3, CD20, CD4, CD8), macrophage and activated microglia (CD68), major…
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