Immunohistochemical analysis of androgen effects on androgen receptor expression in developing Leydig and Sertoli cells.

@article{Shan1997ImmunohistochemicalAO,
  title={Immunohistochemical analysis of androgen effects on androgen receptor expression in developing Leydig and Sertoli cells.},
  author={Li-ying Shan and Caroline Bardin and Matthew Philip Hardy},
  journal={Endocrinology},
  year={1997},
  volume={138 3},
  pages={1259-66}
}
Leydig and Sertoli cells are both targets of androgen action in the testis. Androgen exerts contrasting effects on the two cell types partially inhibiting steroidogenesis in adult Leydig cell and stimulating adult Sertoli cell functions required to support spermatogenesis. The developmental changes in the messenger RNA (mRNA) levels of androgen receptor (AR) also differ between Leydig and Sertoli cells, with Leydig cell AR mRNA being highest on day 35 postpartum, whereas Sertoli cell AR mRNA… CONTINUE READING

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