Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.

@article{Krajewski1994ImmunohistochemicalAO,
  title={Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.},
  author={Stan Stanislaw Krajewski and Sharon Bodrug and Randy D. Gascoyne and Ken W. Berean and Maryla Krajewska and John C. Reed},
  journal={The American journal of pathology},
  year={1994},
  volume={145 3},
  pages={515-25}
}
The Bcl-2 protein blocks programmed cell death and becomes overproduced in many follicular non-Hodgkin's lymphomas as the result of t(14; 18) translocations involving the Bcl-2 gene. Mcl-1 is a recently discovered gene whose encoded protein has significant homology with Bcl-2 but whose function remains unknown. In this study, we compared the in vivo patterns of Bcl-2 and Mcl-1 protein production in normal and neoplastic lymph node biopsies by immunohistochemical means using specific polyclonal… CONTINUE READING

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