Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: Lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotype.

@article{Haberler2006ImmunohistochemicalAO,
  title={Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: Lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotype.},
  author={Christine Haberler and Ute Laggner and Irene Slavc and Thomas Czech and Inge M. Ambros and Peter F. Ambros and H Budka and Johannes Andreas Hainfellner},
  journal={The American journal of surgical pathology},
  year={2006},
  volume={30 11},
  pages={1462-8}
}
Immunohistochemical lack of nuclear INI1 protein expression has been recently described as characteristic finding in atypical teratoid/rhabdoid tumors (AT/RTs), and has been suggested as useful marker to distinguish AT/RTs from other malignant pediatric central nervous system (CNS) tumors. In this study, we examined a large series of malignant pediatric CNS tumors to determine the immunohistochemical expression of INI1 protein in different malignant pediatric tumor entities. Archival paraffin… CONTINUE READING
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