Immunohistochemical analyses of p63 expression in cutaneous tumours

@article{Takeuchi2005ImmunohistochemicalAO,
  title={Immunohistochemical analyses of p63 expression in cutaneous tumours},
  author={Yuko Takeuchi and Atsushi Tamura and Makoto Kamiya and Tomoaki Fukuda and Osamu Ishikawa},
  journal={British Journal of Dermatology},
  year={2005},
  volume={153}
}
1 Belardi MG, Maglione MA, Vighi S et al. Syringoma of the vulva. A case report. J Reprod Med 1994; 12:957–9. 2 Matsumoto K, Satou K, Inamura M et al. A case of eruptive syringoma. Rinsho Derma 2002; 44:87–9 (in Japanese). 3 Shimada Y, Akimoto S, Warita S et al. A case of localized vulval syringoma. Jpn J Clin Dermatol 2003; 57:917–19 (in Japanese). 4 Komatsu H, Kojima M, Tsutsumi N et al. Study of the mechanism of inhibitory action of tranilast on chemical mediator release. Jpn J Pharmacol… 
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TLDR
The data suggest that positive immunostaining for both p63 and CK5/6 in poorly differentiated metastatic carcinomas is highly predictive of a primary tumor of squamous epithelial origin.
Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray
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It is demonstrated that p63, CK 5/6 and CK 14 may be used together in immunohistochemical panels to characterize squamous differentiation in poorly differentiated carcinomas or carcinomas of unknown origin.
p63 identifies keratinocyte stem cells
TLDR
It is shown by clonal analysis that p63 is abundantly expressed by epidermal and limbal holoclones, but is undetectable in paraclones, and will be of practical importance for the clinical application of epithelial cultures in cell therapy as well as for studies on epithelial tumorigenesis.
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
TLDR
It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
p63 is a p53 homologue required for limb and epidermal morphogenesis
TLDR
P63 is essential for several aspects of ectodermal differentiation during embryogenesis, including hair follicles, teeth and mammary glands, which are absent in p63-deficient mice.
Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation.
TLDR
Transgenic/knockout mouse models that have provided evidence linking c-Myc and p63 to different stages of epidermal development and differentiation are discussed, finding that targeted overexpression of c- myc in the basal layer of the epidermis results in an increase in sebaceous gland size and number at the expense of hair follicles.
p63 is the molecular switch for initiation of an epithelial stratification program.
TLDR
The data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis.