Immunohistochemical analyses of p63 expression in cutaneous tumours

  title={Immunohistochemical analyses of p63 expression in cutaneous tumours},
  author={Yuko Takeuchi and Atsushi Tamura and Makoto Kamiya and Tomoaki Fukuda and Osamu Ishikawa},
  journal={British Journal of Dermatology},
1 Belardi MG, Maglione MA, Vighi S et al. Syringoma of the vulva. A case report. J Reprod Med 1994; 12:957–9. 2 Matsumoto K, Satou K, Inamura M et al. A case of eruptive syringoma. Rinsho Derma 2002; 44:87–9 (in Japanese). 3 Shimada Y, Akimoto S, Warita S et al. A case of localized vulval syringoma. Jpn J Clin Dermatol 2003; 57:917–19 (in Japanese). 4 Komatsu H, Kojima M, Tsutsumi N et al. Study of the mechanism of inhibitory action of tranilast on chemical mediator release. Jpn J Pharmacol… 
Expression of p63 in cutaneous metastases.
It is suggested that p63 may be a useful adjunct in the diagnosis of skin carcinomas; however, contrary to what has been previously claimed, expression of p63 does not rule out the metastatic origin of a cutaneous carcinoma.
Evaluation of Invasive Squamous Cell Carcinoma, Seborrheic Keratosis andVerruca Vulgaris in Superficial Shave Biopsies using p16, p53, p63, andPHLDA1 Immunohistochemistry
A panel approach may be utilized to help in the distinction between benign keratoses and carcinoma and may be increasingly critical to promote quality care.
Diagnostic Utility of p63 Expression in the Differential Diagnosis of Pagetoid Squamous Cell Carcinoma In Situ and Extramammary Paget Disease: A Histopathologic Study of 70 Cases
The authors propose the addition of p63 immunostain in the panel of markers when evaluating pagetoid cutaneous neoplasms, and show that all 30 cases of PSCCIS exhibited strong nuclear positivity for p63 in the neoplastic cells, when compared with 0 of 40 cases of primary EMPD.
p63 in Primary Cutaneous Carcinosarcoma
The use of both p63 and routine cytokeratin markers such as AE1/AE3 can increase the sensitivity for distinguishing epithelial cells over a range of differentiation states, which it is proposed will aid in the diagnosis of PCCs.
Value of p63 and podoplanin (D2‐40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases
The results of this study suggest that the combined expression of p63 and podoplanin are a useful adjunct for the diagnosis of skin tumors in the clinical setting of a questionable metastasis and may be relatively specific for distinguishing primary skin tumors from metastatic carcinomas to the skin.
Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma
Atypical fibroxanthoma (AFX), spindle cell squamous cell carcinoma (SCSCC) and spindle cell melanoma are the primary entities in the differential diagnosis of a cytologically atypical spindle cell
p 40 : A p 63 Isoform Useful for Lung Cancer Diagnosis – A Review of the Physiological and Pathological Role of p 63
The physiological and pathological role of p63 isoforms as well as their use as diagnostic markers in lung SCC are reviewed and the use of p40 (in adjunct with TTF-1 and/or Napsin-A) as the best approach to discriminate SCC and lung ADC is recommended.
Primary Cutaneous Carcinosarcomas: A Morphological Histogenetic Concept Revisited
The authors propose defining criteria and a clearly defined morphological approach to contribute to more accurate dermatopathologic diagnoses and provide an unprecedented summary on this neoplastic entity.
p40: A p63 Isoform Useful for Lung Cancer Diagnosis – A Review of the Physiological and Pathological Role of p63
The use of p40 (in adjunct with TTF-1 and/or Napsin-A) as the best approach to discriminate SCC and lung ADC is recommended.


Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas.
The data suggest that positive immunostaining for both p63 and CK5/6 in poorly differentiated metastatic carcinomas is highly predictive of a primary tumor of squamous epithelial origin.
Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray
It is demonstrated that p63, CK 5/6 and CK 14 may be used together in immunohistochemical panels to characterize squamous differentiation in poorly differentiated carcinomas or carcinomas of unknown origin.
p63 identifies keratinocyte stem cells
It is shown by clonal analysis that p63 is abundantly expressed by epidermal and limbal holoclones, but is undetectable in paraclones, and will be of practical importance for the clinical application of epithelial cultures in cell therapy as well as for studies on epithelial tumorigenesis.
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
p63 is a p53 homologue required for limb and epidermal morphogenesis
P63 is essential for several aspects of ectodermal differentiation during embryogenesis, including hair follicles, teeth and mammary glands, which are absent in p63-deficient mice.
Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation.
Transgenic/knockout mouse models that have provided evidence linking c-Myc and p63 to different stages of epidermal development and differentiation are discussed, finding that targeted overexpression of c- myc in the basal layer of the epidermis results in an increase in sebaceous gland size and number at the expense of hair follicles.
p63 is the molecular switch for initiation of an epithelial stratification program.
The data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis.