Immunohistochemical analyses of fibroblast growth factor receptor-1 in the human substantia nigra. Comparison between normal and Parkinson's disease cases

@article{Walker1998ImmunohistochemicalAO,
  title={Immunohistochemical analyses of fibroblast growth factor receptor-1 in the human substantia nigra. Comparison between normal and Parkinson's disease cases},
  author={Douglas G. Walker and Kazuhiro Terai and Akinori Matsuo and Thomas Gerald Beach and PatrickL. Mcgeer},
  journal={Brain Research},
  year={1998},
  volume={794},
  pages={181-187}
}
The use of neurotrophic growth factors as a means of preventing loss of the dopaminergic (DA) neurons in the substantia nigra (SN) is becoming an accepted treatment strategy for Parkinson's disease (PD). In earlier studies, we showed that there was a selective loss of basic fibroblast growth factor (bFGF) immunoreactivity in DA neurons of the SN in PD suggesting that a deficiency of bFGF might contribute to cell death. As a preliminary step to assessing the potential for using bFGF or its… CONTINUE READING
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