Immunohistochemical Localization of Receptor Activator of Nuclear Factor KappaB (RANK) and its Ligand (RANKL) in Human Deciduous Teeth

  title={Immunohistochemical Localization of Receptor Activator of Nuclear Factor KappaB (RANK) and its Ligand (RANKL) in Human Deciduous Teeth},
  author={Stefan Lossd{\"o}rfer and Werner G{\"o}tz and Andreas J{\"a}ger},
  journal={Calcified Tissue International},
Osteoblasts and osteoclasts are involved in bone formation and resorption. RANK and RANKL [receptor activator of nuclear factor kappaB (ligand)], two cytokine-like proteins of the tumor necrosis factor superfamily, are localized on these bone cells and are crucial for the regulation of osteoclastic cell differentiation from hematopoietic precursors and also for the upregulation of mature osteoclasts mediated by cell-to-cell contact and a subsequent cascade of diverse intracellular signaling… 

Immunohistological identification of receptor activator of NF-κB ligand (RANKL) in human, ovine and bovine bone tissues

The result strongly suggests the crucial involvement of osteocytes in terms of orchestrating bone remodelling by influencing differentiation and activation of osteoclasts in the long processes of osteocyte remodelling.

Osteoclastogenesis during mouse tooth germ development is mediated by receptor activator of NFΚ-B ligand (RANKL)

Observations suggest that osteoclastogenesis in the alveolar bone, which is essential for the accommodation of normal tooth development, is mediated by RANK-RANKL signaling.

Expression and role of RANKL in periodontal ligament cells during physiological root-resorption in human deciduous teeth.

Results indicate that PDL cells during the root-resorbing state express RANKL but decrease OPG expression, indicating that expression of RankL likely participates in odontoclastogenesis and activates physiological root resorption.

High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes.

It is demonstrated that gingival CD4(+) T cells are the main cells responsible for higher levels of RANKL observed in human chronic periodontitis patients, and spontaneous and lipopolysaccharide- and phytohemagglutinin-stimulated RankL synthesis were higher in patients than controls.

Immunohistochemical localization of RANK, RANKL and OPG in healthy and arthritic canine elbow joints.

The RANK-RANKL-OPG system is active in bone remodeling in dogs and a surplus of molecules promoting osteoclastogenesis was evident and is indicative of an imbalance between the mediators regulating bone resorption and bone formation.

Physiological and Pathological Bone Resorption New Molecules in the Tumor Necrosis Factor Ligand and Receptor Superfamilies with Importance for

The critical roles in osteoclast differentiation played by RANKL, RANK, and OPG, three novel members of the tumor necrosis factor ligand and receptor superfamilies are revealed, likely to provide a molecular basis for the development of new drugs for the treatment of diseases with excess or deficient osteoclastic bone resorption.

Expression of mRNA for osteoprotegerin and receptor activator of nuclear factor kappa beta ligand (RANKL) during root resorption induced by the application of heavy orthodontic forces on rat molars.

  • E. LowH. ZoellnerO. KharbandaM. A. Darendeliler
  • Biology, Medicine
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
  • 2005

Receptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery

RANKL-positive cells were widely distributed in periodontitis patients giving only partial support to the hypothesis that RANKL expression is restricted to T- and B-cell activation.

The Cytolethal Distending Toxin Induces Receptor Activator of NF-κB Ligand Expression in Human Gingival Fibroblasts and Periodontal Ligament Cells

Investigation of the effect of A. actinomycetemcomitans on the expression of RANKL and OPG in human gingival fibroblasts and periodontal ligament cells found it necessary to note that Cdt is crucial for this induction and may therefore be involved in the pathological bone resorption during the process of localized aggressive periodontitis.

Expressions of RANKL/RANK and M-CSF/c-fms in root resorption lacunae in rat molar by heavy orthodontic force.

RANKL/RANK and M-CSF/c-fms systems may be involved in the process of root resorption by heavy orthodontic force.