Immunohistochemical Detection of Parvovirus B19 in “Gloves and Socks” Papular Purpuric Syndrome: Direct Evidence for Viral Endothelial Involvement. Report of Three Cases and Review of the Literature

@article{Santonja2011ImmunohistochemicalDO,
  title={Immunohistochemical Detection of Parvovirus B19 in “Gloves and Socks” Papular Purpuric Syndrome: Direct Evidence for Viral Endothelial Involvement. Report of Three Cases and Review of the Literature},
  author={C. Santonja and G. Nieto-Gonz{\'a}lez and {\'A}. Santos-Briz and Mar{\'i}a de las Nieves Guti{\'e}rrez Zufiaurre and L. Cerroni and H. Kutzner and L. Requena},
  journal={The American Journal of Dermatopathology},
  year={2011},
  volume={33},
  pages={790-795}
}
Papular-purpuric “gloves and socks” syndrome is a distinctive dermatosis featuring acral pruritus, edema, and petechiae. It has been attributed in most—but not all—reported cases to Parvovirus B19 infection, on the grounds of serological proof of recent infection or detection of viral DNA by polymerase chain reaction in patient serum or biopsies. We report the immunohistochemical detection of Parvovirus B19 VP2 structural protein in the endothelial lining of dermal blood vessels in 3 examples… Expand
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