Immunohistochemical Demonstration of Vascular Endothelial Growth Factor in Vestibular Schwannomas Correlates to Tumor Growth Rate

@article{CayThomasen2003ImmunohistochemicalDO,
  title={Immunohistochemical Demonstration of Vascular Endothelial Growth Factor in Vestibular Schwannomas Correlates to Tumor Growth Rate},
  author={Per Cay{\'e}-Thomasen and Lone Baandrup and Grete Krag Jacobsen and Jens Christian Thomsen and Sven Eric Stangerup},
  journal={The Laryngoscope},
  year={2003},
  volume={113}
}
Objective Vascular endothelial growth factor (VEGF) is one of the most potent mediators of angiogenesis, which is a mandatory process during tumor growth. The present objectives were to determine expression of VEGF in vestibular schwannomas by immunohistochemistry and to examine a possible correlation with symptom duration, tumor size, or growth rate. 
Angiogenesis in vestibular schwannomas: Expression of extracellular matrix factors MMP‐2, MMP‐9, and TIMP‐1
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This study targets the angiogenic process by investigation of tumor expression of M MP‐2, MMP‐9, and tissue inhibitors of metalloproteinase (TIMP)‐1 and a possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored.
VEGF and VEGF Receptor-1 Concentration in Vestibular Schwannoma Homogenates Correlates to Tumor Growth Rate
  • P. Cayé-Thomasen, K. Werther, J. Thomsen
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2005
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It is concluded that VEGF and VEGFR-1 appear to be directly involved in the growth pattern of VS, and correlates with tumor growth rate but not with tumor size, symptom duration, or symptom duration.
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The role of VEGF in hearing loss associated with vestibular schwannomas, otitis media with effusion, and sensorineural hearing loss is highlighted.
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The bFGF and VEGF mRNA expression and the bF GF and V EGF protein expression in sporadic VS correlates to the tumour volume, to the tumor growth index, and to the MVD, which might indicate an angiogenic and neurotrophic influence of these factors and a possible involvement in the growth of sporadic VS.
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There is histopathological evidence for the expression of VEGF in vestibular schwannomas but not for ER and PR, and the application of anti-VEGF therapy as a potential treatment option in the future is necessary.
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The expression levels of VEGF, and vascular endothelial growth factor receptor (VEGFR)-1 and -2 mRNA in 46 intracranial schwannomas by quantitative real-time PCR are determined, and these are correlated with various clinical factors or other molecular markers.
Assessment of antiangiogenic effect of imatinib mesylate on vestibular schwannoma tumors using in vivo corneal angiogenesis assay.
TLDR
The findings of this study indicate that NF2-associated VS has significantly more angiogenic potential than sporadic VS and normal brain tissue, and imatinib may be a potential treatment for VS, especially for NF1-associated lesions that cannot be cured with resection or radiosurgery.
Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.
TLDR
This study shows that anti-VEGF therapy normalizes the vasculature of schwannoma xenografts in nude mice and successfully controls the tumor growth, probably by reestablishing a natural balance between VEGF and semaphorin 3 signaling.
Tumor Biology of Vestibular Schwannoma: A Review of Experimental Data on the Determinants of Tumor Genesis and Growth Characteristics
  • M. de Vries, A. V. D. van der Mey, P. Hogendoorn
  • Biology, Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2015
TLDR
An overview of the literature on vestibular schwannoma biology with special attention to tumor behavior and targeted therapy is provided, and angiogenesis by targeting vascular endothelial growth factor receptor seems to be the most successful pharmacologic strategy.
...
...

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