Immunohistochemical Demonstration of Vascular Endothelial Growth Factor in Vestibular Schwannomas Correlates to Tumor Growth Rate

  title={Immunohistochemical Demonstration of Vascular Endothelial Growth Factor in Vestibular Schwannomas Correlates to Tumor Growth Rate},
  author={Per Cay{\'e}-Thomasen and Lone Baandrup and Grete Krag Jacobsen and Jens Christian Thomsen and Sven Eric Stangerup},
  journal={The Laryngoscope},
Objective Vascular endothelial growth factor (VEGF) is one of the most potent mediators of angiogenesis, which is a mandatory process during tumor growth. The present objectives were to determine expression of VEGF in vestibular schwannomas by immunohistochemistry and to examine a possible correlation with symptom duration, tumor size, or growth rate. 

Angiogenesis in vestibular schwannomas: Expression of extracellular matrix factors MMP‐2, MMP‐9, and TIMP‐1

This study targets the angiogenic process by investigation of tumor expression of M MP‐2, MMP‐9, and tissue inhibitors of metalloproteinase (TIMP)‐1 and a possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored.

VEGF and VEGF Receptor-1 Concentration in Vestibular Schwannoma Homogenates Correlates to Tumor Growth Rate

  • P. Cayé-ThomasenK. Werther J. Thomsen
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2005
It is concluded that VEGF and VEGFR-1 appear to be directly involved in the growth pattern of VS, and correlates with tumor growth rate but not with tumor size, symptom duration, or symptom duration.

The role of vascular endothelial growth factor and vascular stability in diseases of the ear

The role of VEGF in hearing loss associated with vestibular schwannomas, otitis media with effusion, and sensorineural hearing loss is highlighted.

Expression of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor in Sporadic Vestibular Schwannomas Correlates to Growth Characteristics

The bFGF and VEGF mRNA expression and the bF GF and V EGF protein expression in sporadic VS correlates to the tumour volume, to the tumor growth index, and to the MVD, which might indicate an angiogenic and neurotrophic influence of these factors and a possible involvement in the growth of sporadic VS.

Expression of VEGF and its receptor genes in intracranial schwannomas

The expression levels of VEGF, and vascular endothelial growth factor receptor (VEGFR)-1 and -2 mRNA in 46 intracranial schwannomas by quantitative real-time PCR are determined, and these are correlated with various clinical factors or other molecular markers.

Assessment of antiangiogenic effect of imatinib mesylate on vestibular schwannoma tumors using in vivo corneal angiogenesis assay.

The findings of this study indicate that NF2-associated VS has significantly more angiogenic potential than sporadic VS and normal brain tissue, and imatinib may be a potential treatment for VS, especially for NF1-associated lesions that cannot be cured with resection or radiosurgery.

Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.

This study shows that anti-VEGF therapy normalizes the vasculature of schwannoma xenografts in nude mice and successfully controls the tumor growth, probably by reestablishing a natural balance between VEGF and semaphorin 3 signaling.

Tumor Biology of Vestibular Schwannoma: A Review of Experimental Data on the Determinants of Tumor Genesis and Growth Characteristics

  • M. de VriesA. V. D. van der MeyP. Hogendoorn
  • Biology, Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2015
An overview of the literature on vestibular schwannoma biology with special attention to tumor behavior and targeted therapy is provided, and angiogenesis by targeting vascular endothelial growth factor receptor seems to be the most successful pharmacologic strategy.

Immunohistochemical demonstration and semi-quantitation of vascular endothelial growth factor in recurrent versus non-recurrent nasal polyps

The findings indicate that the level of immunohistochemical expression of VEGF in recurrent and non-recurrent nasal polyposis is equivalent and cannot predict a subsequent recurrence, and the expression ofVEGF is not upregulated in patients with asthma.



Vascular endothelial growth factor: molecular and biological aspects.

  • N. Ferrara
  • Medicine
    Current topics in microbiology and immunology
  • 1999
Angiogenesis is implicated in the pathogenesis of a variety of disorders: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis and psoriasis.

Clinicopathologic growth factors in vestibular schwannomas: a morphological and immunohistochemical study of 69 tumours.

Vessel density is determinant for sporadic acoustic neuroma growth especially for a short clinical course, according to a retrospective study with 69 paraffin-embedded tumours.

Transforming growth factor-beta1 expression in human acoustic neuroma.

TGF-beta1 could participate in the biological behavior of AN, particularly as an important factor of tumor growth prediction by allowing rapidly progressive or potentially recurrent tumors to be differentiated from slow-growing tumors that are unlikely to recur.

Proliferation indices of vestibular schwannomas by Ki-67 and proliferating cell nuclear antigen.

The results suggest that tumor growth is not homogeneous within a tumor, but that proliferation may be more active near the surface.

Nerve growth factor receptor immunoreactivity in human benign peripheral nerve sheath tumor

In traumatic neuroma, staining for the NGF receptor was more intense in the perineurium than in the endoneurial cells, and immunostaining by the anti-S-100β protein antibody in adjacent sections suggested that the vast majority of NGF receptors-positive cells were also positive for S- 100β protein.

Immunohistochemical measurement of tumor vascular endothelial growth factor in breast cancer. A more reliable predictor of tumor stage than microvessel density or serum vascular endothelial growth factor.

Measurement of tumor V EGF, as an indicator of angiogenesis, is more reliable prognostically than measurement of microvessel density or serum VEGF.

Angiogenesis from the eighth cranial nerve to vestibular schwannomas.

It is suggested that sudden hearing loss in vestibular schwannoma patients may be related to the disruption of such blood vessels, and surgical injury to these blood vessels may cause postoperative hearing loss despite preservation of the cochlear nerve.

Vestibular Schwannoma Growth: The Continuing Controversy

Investigation of the growth of vestibular schwannoma in a series of 123 patients with 127 tumors allocated to the “wait and scan” group in the period 1973-1999 finds no significant differences between the groups.