Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver.

@article{Yang2017ImmunohistochemicalCO,
  title={Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver.},
  author={Zhaohai Yang and David S. Klimstra and Ralph H. Hruban and Laura H. Tang},
  journal={The American journal of surgical pathology},
  year={2017},
  volume={41 7},
  pages={915-922}
}
Metastatic neoplasms of unknown primary site pose a major challenge to patient management. As targeted therapies are now being tailored to neuroendocrine tumors (NETs) of different primary sites, identifying the origin of metastatic NETs has become increasingly important. Compared with more extensive efforts on metastatic adenocarcinomas of unknown primary, the literature on metastatic NETs (often to the liver) is relatively sparse and most studies are based on primary tumors. We sought to… CONTINUE READING