Immunohistochemical Analysis for Neural Markers of the Lateral Retinaculum in Patients with Isolated Symptomatic Patellofemoral Malalignment.

Abstract

We evaluated 13 lateral retinacula excised at the time of Insall proximal realignments or isolated lateral retinacular releases performed in patients with isolated symptomatic patellofemoral malalignment recalcitrant to nonoperative treatment. Evaluation was performed by means of conventional histologic and immunohistochemical analysis for neural markers (S-100 protein, neurofilament protein, substance P, and neural growth factor). The observations reported here provide a neuroanatomic basis for anterior knee pain syndrome in active young patients with isolated symptomatic patellofemoral malalignment and support the clinical observation that the lateral retinaculum may have a key role in the origin of this pain as a result of increased neural growth factor production, which induces proliferation of nociceptive axons, mainly in a perivascular location.

DOI: 10.1177/03635465000280051801

4 Figures and Tables

050100150'02'04'06'08'10'12'14'16
Citations per Year

250 Citations

Semantic Scholar estimates that this publication has 250 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{SanchisAlfonso2000ImmunohistochemicalAF, title={Immunohistochemical Analysis for Neural Markers of the Lateral Retinaculum in Patients with Isolated Symptomatic Patellofemoral Malalignment.}, author={Vicente Sanchis-Alfonso and Esther Rosell{\'o}-Sastre}, journal={The American journal of sports medicine}, year={2000}, volume={28 5}, pages={725-731} }