Immunohistochemical (IHC) HER-2/neu and fluorescent-in situ hybridization (FISH) gene amplification of breast cancer in Indian women.

@article{Singhai2011ImmunohistochemicalH,
  title={Immunohistochemical (IHC) HER-2/neu and fluorescent-in situ hybridization (FISH) gene amplification of breast cancer in Indian women.},
  author={Rajeev Singhai and V. W. Patil and A L Patil},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2011},
  volume={12 1},
  pages={179-83}
}
BACKGROUND The concordance rate between immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) results for HER2/neu according to clinical performance is controversial. The present prospective study was theerefore conducted in Indian breast cancer patients. METHODS Fifty cases (n=50) of invasive duct cancer of breast tested for HER-2/neu by IHC and scored as 0, 1+, 2+ and 3+ by pathologists were further analyzed by FISH using a commercially available double-color probe, and… CONTINUE READING